Electrospun core–sheath PCL nanofibers loaded with nHA and simvastatin and their potential bone regeneration applications

Introduction: Drugs and biocompatible nanoparticles have raised significant potential in advancing the bone regeneration. Electrospinning technology enables full realization of value drugs nanoparticles. Methods: In this study, we successfully fabricated core–sheath nanofibers solely composed polycaprolactone (PCL) polymer. Simvastatin (SIM) was confined to core while nanohydroxyapatite (nHA) loaded on nanofiber surface. Results: All prepared exhibited a cylindrical micromorphology, structure exploited using Transmission Electron Microscope. X-ray pattern results indicated that SIM an amorphous state within nanofibers, Fourier Transform InfraRed spectroscopy showed excellent chemical compatibility among SIM, nHA, PCL. The actual loading nHA determined by thermogravimetric test due high melting point nHA. Core–sheath could release for 672 h, which attributed structure. Furthermore, with or had positive impact cell proliferation, displaying most favorable proliferation behavior. Discussion: Such synergistic facilitation strategy based materials nanostructure may encourage researchers exploit new biomedical future.